HSPB11

Across TCGA cell cohorts, HSPB11 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,829 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HSPB11-associated GO terms across cancer lineages are Regulation of metaphase/anaphase transition of cell cycle, Negative regulation of metaphase/anaphase transition of cell cycle, and Negative regulation of chromosome separation. Each is linked with HSPB11 in more than 15 cancer types. Because this analysis shows association rather than direction, both HSPB11-to-partner and partner-to-HSPB11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of metaphase/anaphase transition of cell cycle grouped by HSPB11-low versus HSPB11-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HSPB11→partner) and Y-score (partner→HSPB11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Regulation of metaphase/anaphase transition of cell cycle →	+0.109	+0.969	<.001	<.001	3	16
URINARY_TRACT	Negative regulation of metaphase/anaphase transition of cell cycle →	+0.133	+1.161	<.001	<.001	3	16
URINARY_TRACT	Negative regulation of chromosome separation →	+0.133	+1.161	<.001	<.001	3	16
SOFT_TISSUE	Regulation of mitotic metaphase/anaphase transition →	+0.113	+0.979	<.001	<.001	3	16
SOFT_TISSUE	Regulation of mitotic sister chromatid separation →	+0.144	+1.056	<.001	<.001	3	15
LIVER	Spindle checkpoint signaling →	+0.100	+0.917	.005	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,829 associations by consensus.

Regulation of metaphase/anaphase transition of cell cycle by HSPB11 expression — SOFT_TISSUE

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