HSPB1

Across TCGA patient cohorts, HSPB1 protein abundance is significantly associated with the RNA expression of many other genes, with 17,776 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HSPB1-associated genes across cancer lineages are TMEM120A, HSPB1P1, and BLM. Each is linked with HSPB1 in more than 5 cancer types. Because this analysis shows association rather than direction, both HSPB1-to-partner and partner-to-HSPB1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HSPB1 versus TMEM120A in OV, with a Pearson correlation of 0.38.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSPB1→partner) and Y-score (partner→HSPB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TMEM120A →	+0.663	+0.508	.001	<.001	3	6
BRCA	HSPB1P1 →	+1.514	+0.702	<.001	<.001	3	6
HNSC	BLM →	-0.838	-0.477	.001	.003	3	6
BRCA	GAMT →	+1.091	+0.525	<.001	<.001	3	5
COAD	ZCCHC24 →	+0.801	+0.565	<.001	<.001	3	5
HNSC	RARG →	+0.909	+0.568	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,776 associations by consensus.

HSPB1 vs TMEM120A — OV

Explore this scatter interactively →