HSPB1

Across TCGA pan-cancer cohorts, HSPB1 RNA is linked to patient survival in 30 of 34 cancer types, making it the most broadly survival-associated HSPB1 data layer compared with 1 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in brain lower grade glioma (LGG), where higher HSPB1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated HSPB1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUSC show a favorable association.

LGG, LIHC, and READ are the cancer types where HSPB1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	DFS	Median	All	0.598	0.864	<.001	54	view →
LIHC	OS	Tertile	III,IV	0.475	0.825	<.001	48	view →
READ	OS	Quartile	II,III,IV	0.564	1.000	.003	47	view →
KIRP	OS	Tertile	All	0.826	0.946	.002	36	view →
MESO	OS	Median	III,IV	0.261	0.501	<.001	34	view →
UCEC	OS	Quartile	All	0.892	0.742	.005	26	view →
GBM	OS	Median	All	0.284	0.532	.002	25	view →
LAML	DFS	Quartile	All	0.428	0.674	.015	24	view →
LUSC	OS	Quartile	II,III,IV	0.797	0.378	.004	20	view →
ACC	DFS	Tertile	III,IV	0.660	0.163	.002	19	view →
COAD	DFS	Quartile	All	0.600	0.762	.007	17	view →
KICH	OS	Median	All	0.969	0.766	.012	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 30 lineages.

HSPB1–LGG (DFS)

Open the LGG breakdown →