Across TCGA patient cohorts, HSP90B3P mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HSP90B3P-associated genes across cancer lineages are MEK1, MSH2, and p62 Lck ligand. Each is linked with HSP90B3P in more than 1 cancer types. Because this analysis shows association rather than direction, both HSP90B3P-to-partner and partner-to-HSP90B3P results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSP90B3P→partner) and Y-score (partner→HSP90B3P) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.617	+3.321	.001	.010	3	1
UCEC	MSH2 →	-0.278	-2.990	.021	.036	3	1
UCEC	p62 Lck ligand →	+0.588	+3.321	<.001	.010	3	1
UCEC	TIGAR →	+0.171	+2.196	.032	.034	2	2
UCEC	ATM →	-0.617	-3.321	.009	.010	3	1
UCEC	Bax →	+0.289	+2.817	.021	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Exploration

HSP90B3P survival (RNA) · tumor vs normal (RNA) · all HSP90B3P data types