Across TCGA pan-cancer cohorts, HSP90B3P RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of HSP90B3P’s most consistent transcriptional readouts.
The strongest signal is observed in lung adenocarcinoma (LUAD), where HSP90B3P RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HSP90B3P is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.
LUAD, COAD, and HNSC are the cancer types where HSP90B3P tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HSP90B3P RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.