Across TCGA pan-cancer cohorts, HSP90B3P RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated HSP90B3P data layer compared with 4 for mutation status.
The strongest signal is observed in uveal melanoma (UVM), where higher HSP90B3P RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated HSP90B3P expression acts as an unfavorable survival marker, although some lineages such as PRAD and COAD show a favorable association.
UVM, ACC, and STAD are the cancer types where HSP90B3P RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.