HSF4

Across TCGA patient cohorts, HSF4 mutation is significantly associated with the RNA expression of many other genes, with 618 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HSF4-associated genes across cancer lineages are RNVU1-17, RNU6-1318P, and RN7SL134P. Each is linked with HSF4 in more than 1 cancer types. Because this analysis shows association rather than direction, both HSF4-to-partner and partner-to-HSF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNVU1-17 grouped by HSF4-low versus HSF4-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSF4→partner) and Y-score (partner→HSF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNVU1-17 →	+0.251	+5.822	<.001	.003	3	2
BLCA	RNU6-1318P →	+0.321	+4.588	<.001	.008	3	2
UCEC	RN7SL134P →	+0.122	+2.599	.007	.009	3	2
CESC	EIF4BP4 →	+0.028	+5.418	<.001	.005	3	2
BLCA	VENTXP8 →	+0.567	+5.213	<.001	.001	3	2
CESC	PNLIPP1 →	+0.063	+5.103	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 618 associations by consensus.

RNVU1-17 by HSF4 expression — HNSC

Explore this box plot interactively →