HSF4

Across TCGA pan-cancer cohorts, HSF4 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of HSF4’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where HSF4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HSF4 is over-expressed in tumor, although a few such as BRCA show the opposite, repressed pattern.

KIRC, COAD, and LIHC are the cancer types where HSF4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HSF4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	+3.364	<.001	12	view →
COAD	All	IV	+2.335	<.001	10	view →
LIHC	Female	II,III,IV	+1.634	<.001	9	view →
KIRP	All	III,IV	+1.543	<.001	9	view →
BRCA	Female	All	−0.600	<.001	6	view →
LUAD	Female	All	+0.850	<.001	5	view →
CHOL	All	All	+2.156	<.001	3	view →
READ	All	All	+1.496	<.001	3	view →
PAAD	All	All	+1.322	.015	2	view →
UCEC	All	All	+0.859	.001	2	view →
KICH	Male	IV	+0.733	<.001	2	view →
PRAD	All	All	+0.536	.003	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

HSF4–KIRC

Open the KIRC breakdown →