HSD17B6

Across TCGA patient cohorts, HSD17B6 mutation is significantly associated with the RNA expression of many other genes, with 353 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HSD17B6-associated genes across cancer lineages are RNA5SP412, OR10T2, and OR2A4. Each is linked with HSD17B6 in more than 1 cancer types. Because this analysis shows association rather than direction, both HSD17B6-to-partner and partner-to-HSD17B6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP412 grouped by HSD17B6-low versus HSD17B6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSD17B6→partner) and Y-score (partner→HSD17B6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP412 →	+0.940	+2.967	<.001	<.001	3	2
LUAD	OR10T2 →	+0.069	+7.599	<.001	<.001	3	2
SKCM	OR2A4 →	+0.053	+4.132	<.001	<.001	3	1
SKCM	OR51A8P →	+0.019	+4.475	<.001	.005	3	1
SKCM	RNA5SP113 →	+0.171	+4.475	<.001	.005	3	1
SKCM	PDCL3P6 →	+0.094	+3.443	.004	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 353 associations by consensus.

RNA5SP412 by HSD17B6 expression — UCEC

Explore this box plot interactively →