HSD17B6

Across TCGA pan-cancer cohorts, HSD17B6 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated HSD17B6 data layer compared with 3 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher HSD17B6 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated HSD17B6 expression acts as an unfavorable survival marker, although some lineages such as SKCM and UCS show a favorable association.

KIRP, SKCM, and UCS are the cancer types where HSD17B6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Tertile	All	0.555	0.800	<.001	177	view →
SKCM	OS	Quartile	III,IV	0.858	0.622	<.001	87	view →
UCS	OS	Quartile	II,III,IV	0.759	0.313	.001	58	view →
LIHC	DFS	Quartile	All	0.381	0.232	<.001	52	view →
LUAD	OS	Median	All	0.868	0.754	<.001	44	view →
MESO	DFS	Quartile	All	0.556	0.265	.005	42	view →
KICH	DFS	Median	II,III,IV	0.598	0.911	.011	34	view →
SARC	OS	Quartile	All	0.871	0.589	.002	16	view →
DLBC	DFS	Median	II,III,IV	1.000	0.331	.006	15	view →
COAD	DFS	Median	All	0.396	0.578	.012	12	view →
LUSC	DFS	Tertile	III,IV	0.753	0.512	.009	12	view →
UVM	OS	Median	All	0.937	0.768	.020	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

HSD17B6–KIRP (DFS)

Open the KIRP breakdown →