HSD11B1L

Across TCGA patient cohorts, HSD11B1L mutation is significantly associated with the RNA expression of many other genes, with 63 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible HSD11B1L-associated genes across cancer lineages are MIR3692, MIR6718, and MIR6859-4. Each is linked with HSD11B1L in more than 1 cancer types. Because this analysis shows association rather than direction, both HSD11B1L-to-partner and partner-to-HSD11B1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3692 grouped by HSD11B1L-low versus HSD11B1L-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSD11B1L→partner) and Y-score (partner→HSD11B1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR3692 →	+0.211	+4.147	<.001	.008	3	2
BLCA	MIR6718 →	+0.621	+4.588	<.001	.008	3	1
UCEC	MIR6859-4 →	+0.572	+3.278	.001	.005	3	1
SKCM	LINC02540 →	+0.042	+4.475	<.001	.005	3	1
SKCM	RPL21P23 →	+0.111	+3.274	.007	.004	3	1
SKCM	RNA5SP246 →	+0.396	+3.836	.007	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 63 associations by consensus.

MIR3692 by HSD11B1L expression — SKCM

Explore this box plot interactively →