HSD11B1L

Across TCGA pan-cancer cohorts, HSD11B1L RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated HSD11B1L data layer compared with 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher HSD11B1L RNA is associated with better overall survival. In most high-consensus cancer types, elevated HSD11B1L expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

HNSC, ACC, and LUAD are the cancer types where HSD11B1L RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	IV	0.707	0.501	<.001	99	view →
ACC	DFS	Tertile	All	0.340	0.748	<.001	71	view →
LUAD	DFS	Median	II,III,IV	0.405	0.128	.003	59	view →
UCS	DFS	Median	IV	0.367	0.952	.001	48	view →
LIHC	OS	Tertile	All	0.691	0.869	.002	43	view →
MESO	DFS	Tertile	All	0.317	0.484	.021	22	view →
LGG	OS	Median	All	0.934	0.857	.001	20	view →
PRAD	DFS	Tertile	All	0.688	0.901	<.001	18	view →
READ	DFS	Median	All	0.373	0.736	.004	16	view →
SKCM	OS	Tertile	All	0.856	0.911	.007	14	view →
PAAD	OS	Quartile	All	0.649	0.291	.008	14	view →
ESCA	OS	Median	All	1.000	0.659	.020	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

HSD11B1L–HNSC (OS)

Open the HNSC breakdown →