HSD11B1L

Across TCGA pan-cancer cohorts, HSD11B1L RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of HSD11B1L’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where HSD11B1L RNA is repressed in tumor relative to normal tissue. In most cancer types HSD11B1L is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and LIHC are the cancer types where HSD11B1L tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HSD11B1L RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−0.614	<.001	10	view →
KICH	Female	II,III,IV	−1.758	<.001	8	view →
LIHC	All	All	+0.498	<.001	6	view →
CHOL	All	All	+1.403	<.001	5	view →
COAD	All	All	+0.390	<.001	5	view →
KIRP	All	IV	+0.799	.024	4	view →
BRCA	All	All	+0.250	.008	4	view →
THCA	Male	II,III,IV	−0.242	.015	4	view →
LUAD	All	IV	+0.574	.023	2	view →
PRAD	All	All	−0.177	.009	2	view →
STAD	Female	III,IV	−0.905	.009	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

HSD11B1L–KIRC

Open the KIRC breakdown →