HSCB

Across TCGA patient cohorts, HSCB mutation is significantly associated with the RNA expression of many other genes, with 252 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible HSCB-associated genes across cancer lineages are MIR7155, MTND6P16, and MIR6804. Each is linked with HSCB in more than 2 cancer types. Because this analysis shows association rather than direction, both HSCB-to-partner and partner-to-HSCB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR7155 grouped by HSCB-low versus HSCB-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSCB→partner) and Y-score (partner→HSCB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MIR7155 →	+0.843	+5.368	<.001	.005	3	3
LUSC	MTND6P16 →	+0.137	+6.733	<.001	<.001	3	3
UCEC	MIR6804 →	+0.637	+2.694	.002	.006	3	2
HNSC	RNU6-618P →	+0.367	+5.015	<.001	.009	3	2
HNSC	RNA5SP451 →	+0.514	+6.468	<.001	.001	3	2
SKCM	RNU6-991P →	+0.184	+4.993	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 252 associations by consensus.

MIR7155 by HSCB expression — HNSC

Explore this box plot interactively →