HSCB

Across TCGA pan-cancer cohorts, HSCB RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of HSCB’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where HSCB RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HSCB is over-expressed in tumor, although a few such as KICH and BLCA show the opposite, repressed pattern.

KIRC, KICH, and LUSC are the cancer types where HSCB tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HSCB RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	+0.699	<.001	12	view →
KICH	Female	II,III,IV	−0.972	<.001	5	view →
LUSC	All	All	+0.514	<.001	5	view →
HNSC	All	III,IV	+0.407	.002	5	view →
LUAD	Female	All	+0.416	<.001	3	view →
LIHC	All	All	+0.307	.001	3	view →
CHOL	Male	All	+0.818	<.001	2	view →
BLCA	All	IV	−0.418	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

HSCB–KIRC

Open the KIRC breakdown →