HRH4

Across TCGA cell cohorts, HRH4 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HRH4-associated genes across cancer lineages are C6orf118, OR52H1, and H2BC3. Each is linked with HRH4 in more than 1 cancer types. Because this analysis shows association rather than direction, both HRH4-to-partner and partner-to-HRH4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C6orf118 grouped by HRH4-low versus HRH4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HRH4→partner) and Y-score (partner→HRH4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C6orf118 →	+0.125	+3.793	<.001	.007	3	1
LARGE_INTESTINE	OR52H1 →	+0.031	+4.347	<.001	.001	3	1
LARGE_INTESTINE	H2BC3 →	+0.222	+4.196	<.001	.002	3	1
LARGE_INTESTINE	OR6Q1 →	+0.018	+4.437	<.001	.004	3	1
SKIN	OXT →	+0.063	+4.977	<.001	.007	3	1
SKIN	AVPR1B →	+0.006	+5.415	.007	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

C6orf118 by HRH4 expression — LARGE_INTESTINE

Explore this box plot interactively →