HRH4

Across TCGA pan-cancer cohorts, HRH4 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated HRH4 data layer compared with 4 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher HRH4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated HRH4 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCS show a favorable association.

UCEC, UVM, and STAD are the cancer types where HRH4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	All	0.554	0.781	<.001	104	view →
UVM	OS	Median	All	0.429	0.744	.001	82	view →
STAD	OS	Tertile	II,III,IV	0.395	0.720	<.001	81	view →
HNSC	DFS	Median	IV	0.763	0.575	.001	56	view →
LGG	DFS	Median	All	0.653	0.817	<.001	54	view →
THCA	OS	Quartile	All	0.874	0.985	.002	51	view →
MESO	DFS	Tertile	All	0.165	0.606	.005	24	view →
UCS	DFS	Median	IV	0.952	0.367	.001	24	view →
LAML	DFS	Median	All	0.571	0.247	.002	22	view →
LUAD	OS	Median	All	0.855	0.773	.004	19	view →
COAD	OS	Quartile	All	0.948	0.752	.005	14	view →
READ	DFS	Tertile	IV	0.917	0.423	.006	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

HRH4–UCEC (OS)

Open the UCEC breakdown →