HRH4

Across TCGA cell cohorts, HRH4 mutation is significantly associated with the mutation status of many other genes, with 2,590 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HRH4-associated genes across cancer lineages are EXD3, SLAMF6, and DCAF13. Each is linked with HRH4 in more than 3 cancer types. Because this analysis shows association rather than direction, both HRH4-to-partner and partner-to-HRH4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EXD3 grouped by HRH4-low versus HRH4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HRH4→partner) and Y-score (partner→HRH4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	EXD3 →	+2.459	+3.321	.005	.005	1	4
BLOOD_Leukemia	SLAMF6 →	+5.560	+4.736	.003	.003	1	3
SKIN	DCAF13 →	+4.392	+4.392	.009	.009	1	3
SKIN	PDZRN4 →	+3.655	+4.906	.001	.001	1	3
SKIN	MTBP →	+5.392	+4.824	.004	.004	1	3
SKIN	TLR5 →	+4.392	+5.357	<.001	<.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,590 associations by consensus.

EXD3 by HRH4 expression — LARGE_INTESTINE

Explore this box plot interactively →