HR

Across TCGA patient cohorts, HR RNA expression is significantly associated with the protein abundance of many other proteins, with 19,223 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HR-associated proteins across cancer lineages are GCC2, GMPPA, and USO1. Each is linked with HR in more than 4 cancer types. Because this analysis shows association rather than direction, both HR-to-partner and partner-to-HR results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HR versus GCC2 in LSCC, with a Pearson correlation of -0.44.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HR→partner) and Y-score (partner→HR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GCC2 →	-0.266	-1.789	<.001	<.001	3	5
LSCC	GMPPA →	-0.276	-1.275	<.001	<.001	3	5
LSCC	USO1 →	-0.252	-1.831	.001	<.001	3	4
HNSC	SLC3A2 →	+0.591	+1.015	<.001	<.001	3	4
HNSC	SPTBN2 →	+0.665	+0.920	<.001	<.001	3	4
BRCA	SPTBN2_S1255 →	+1.753	+2.336	.002	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,223 associations by consensus.

HR vs GCC2 — LSCC

Explore this scatter interactively →