HR

Across TCGA pan-cancer cohorts, HR RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated HR data layer compared with 11 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher HR RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated HR expression acts as an unfavorable survival marker, although some lineages such as LUSC and CESC show a favorable association.

LUSC, CESC, and HNSC are the cancer types where HR RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	DFS	Median	II,III,IV	0.795	0.618	<.001	39	view →
CESC	DFS	Median	All	0.873	0.768	.004	34	view →
HNSC	DFS	Tertile	IV	0.384	0.195	.012	31	view →
ACC	OS	Median	IV	0.799	0.287	.006	30	view →
LGG	DFS	Tertile	All	0.841	0.685	<.001	25	view →
UCEC	OS	Quartile	All	0.497	0.832	.005	22	view →
ESCA	OS	Tertile	IV	0.856	0.219	.024	18	view →
SCLC	DFS	Median	II,III,IV	0.469	0.157	.019	16	view →
MESO	OS	Tertile	II,III,IV	0.804	0.358	.012	15	view →
KIRC	DFS	Quartile	All	0.891	0.586	<.001	13	view →
UCS	OS	Tertile	II,III,IV	0.285	0.624	.019	12	view →
UVM	DFS	Tertile	III,IV	0.730	0.180	.005	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

HR–LUSC (DFS)

Open the LUSC breakdown →