HPS4

protein abundance — cross-omics
Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, HPS4 protein abundance is significantly associated with the RNA expression of many other genes, with 3,774 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HPS4-associated genes across cancer lineages are SPTBN1, EDN3, and ABHD2. Each is linked with HPS4 in more than 1 cancer types. Because this analysis shows association rather than direction, both HPS4-to-partner and partner-to-HPS4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HPS4 versus SPTBN1 in UCEC, with a Pearson correlation of 0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HPS4→partner) and Y-score (partner→HPS4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECSPTBN1 →+0.823+0.572<.001<.00132
UCECEDN3 →+2.810+0.641<.001<.00132
UCECABHD2 →+0.848+0.402<.001<.00132
UCECSERP2 →+0.737+0.408.002.00132
UCECUTRN →+0.787+0.559<.001.00132
UCECABHD6 →+1.119+0.712<.001<.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 3,774 associations by consensus.

HPS4 vs SPTBN1 — UCEC

Per-sample scatter of HPS4 vs SPTBN1 in UCEC (Pearson r = 0.36).

Explore this scatter interactively →

Exploration