HPS4

Across TCGA pan-cancer cohorts, HPS4 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated HPS4 data layer compared with 4 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher HPS4 RNA is associated with better overall survival. In most high-consensus cancer types, elevated HPS4 expression acts as an unfavorable survival marker, although some lineages such as BRCA and ESCA show a favorable association.

BRCA, ACC, and ESCA are the cancer types where HPS4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Tertile	All	0.986	0.937	<.001	57	view →
ACC	DFS	Tertile	All	0.178	0.730	<.001	55	view →
ESCA	OS	Median	All	0.815	0.582	<.001	41	view →
LIHC	OS	Median	All	0.708	0.835	<.001	39	view →
READ	OS	Tertile	II,III,IV	0.903	0.279	.001	37	view →
UCEC	DFS	Quartile	III,IV	0.894	0.697	.011	26	view →
LUSC	DFS	Quartile	III,IV	0.236	0.903	.001	22	view →
SKCM	OS	Tertile	All	0.244	0.447	<.001	19	view →
GBM	DFS	Tertile	All	0.438	0.228	.011	18	view →
LUAD	DFS	Tertile	IV	0.664	0.941	.022	12	view →
SCLC	OS	Tertile	All	0.461	0.225	.011	12	view →
HNSC	OS	Quartile	All	0.277	0.538	.013	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

HPS4–BRCA (OS)

Open the BRCA breakdown →