HPS4

Across TCGA pan-cancer cohorts, HPS4 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of HPS4’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where HPS4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HPS4 is over-expressed in tumor, although a few such as THCA and BRCA show the opposite, repressed pattern.

HNSC, KIRC, and LIHC are the cancer types where HPS4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HPS4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	II,III,IV	+0.808	<.001	12	view →
KIRC	Female	III,IV	+0.804	<.001	12	view →
LIHC	Female	II,III,IV	+0.965	<.001	9	view →
COAD	Female	All	+0.732	<.001	9	view →
BLCA	All	III,IV	+0.647	<.001	9	view →
THCA	All	All	−0.350	<.001	7	view →
CHOL	Male	All	+1.920	<.001	5	view →
READ	Female	All	+1.034	<.001	5	view →
LUSC	Male	II,III,IV	+0.829	<.001	5	view →
STAD	Male	All	+0.773	<.001	5	view →
KICH	All	II,III,IV	+0.505	.004	5	view →
BRCA	Female	All	−0.201	.002	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

HPS4–HNSC

Open the HNSC breakdown →