HPS4

Across TCGA patient cohorts, HPS4 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HPS4-associated genes across cancer lineages are ASNS, C-Raf, and GAPDH. Each is linked with HPS4 in more than 2 cancer types. Because this analysis shows association rather than direction, both HPS4-to-partner and partner-to-HPS4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by HPS4-low versus HPS4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HPS4→partner) and Y-score (partner→HPS4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.383	+1.765	<.001	.011	3	3
UCEC	C-Raf →	+0.154	+1.999	<.001	.002	3	3
UCEC	GAPDH →	+0.371	+1.906	.020	.014	3	2
UCEC	mTOR_pS2448 →	-0.124	-1.918	.005	.001	3	2
UCEC	Notch1 →	+0.155	+1.807	<.001	<.001	3	2
UCEC	PCNA →	+0.171	+1.736	.008	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

ASNS by HPS4 expression — UCEC

Explore this box plot interactively →