HPS4

Across TCGA cell cohorts, HPS4 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,301 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HPS4-associated GO terms across cancer lineages are Negative regulation of chromosome condensation, Symbiont-mediated disruption of host cellular anatomical structure, and Symbiont-mediated disruption of host anatomical structure. Each is linked with HPS4 in more than 14 cancer types. Because this analysis shows association rather than direction, both HPS4-to-partner and partner-to-HPS4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of chromosome condensation grouped by HPS4-low versus HPS4-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HPS4→partner) and Y-score (partner→HPS4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Negative regulation of chromosome condensation →	+0.181	+0.973	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Symbiont-mediated disruption of host cellular anatomical structure →	+0.126	+0.738	.001	.003	2	15
UPPER_AERODIGESTIVE_TRACT	Symbiont-mediated disruption of host anatomical structure →	+0.126	+0.738	.001	.003	2	15
LUNG_NSCLC_LUSC	DNA topological change →	+0.149	+0.847	<.001	.002	2	14
BLOOD_Myeloma	Positive regulation of macrophage proliferation →	+0.184	+1.082	.001	.006	3	13
STOMACH	Regulation of intracellular steroid hormone receptor signaling pathway →	+0.097	+1.125	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,301 associations by consensus.

Negative regulation of chromosome condensation by HPS4 expression — SOFT_TISSUE

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