HPS4

Across TCGA cell cohorts, HPS4 mutation is significantly associated with the RNA expression of many other genes, with 93 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HPS4-associated genes across cancer lineages are SSTR5, CA2, and MAGEB4. Each is linked with HPS4 in more than 1 cancer types. Because this analysis shows association rather than direction, both HPS4-to-partner and partner-to-HPS4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SSTR5 grouped by HPS4-low versus HPS4-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HPS4→partner) and Y-score (partner→HPS4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	SSTR5 →	+0.011	+4.350	<.001	.005	3	2
LARGE_INTESTINE	CA2 →	+2.522	+3.212	<.001	.006	3	1
LARGE_INTESTINE	MAGEB4 →	+0.009	+3.192	<.001	.002	3	1
LARGE_INTESTINE	KCNJ5 →	+0.639	+3.385	<.001	.004	3	1
LARGE_INTESTINE	IL9R →	+0.431	+3.212	.003	.006	3	1
LARGE_INTESTINE	RWDD2A →	+0.466	+3.299	.006	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 93 associations by consensus.

SSTR5 by HPS4 expression — BLOOD_Lymphoma

Explore this box plot interactively →