HPRT1

Across TCGA patient cohorts, HPRT1 protein abundance is significantly associated with the RNA expression of many other genes, with 13,130 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HPRT1-associated genes across cancer lineages are GINS2, RFWD3, and RHNO1. Each is linked with HPRT1 in more than 4 cancer types. Because this analysis shows association rather than direction, both HPRT1-to-partner and partner-to-HPRT1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HPRT1 versus GINS2 in HNSC, with a Pearson correlation of 0.29.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HPRT1→partner) and Y-score (partner→HPRT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	GINS2 →	+0.868	+0.311	.001	.002	3	5
OV	RFWD3 →	+0.816	+0.576	<.001	.001	3	5
HNSC	RHNO1 →	+0.693	+0.292	<.001	<.001	3	5
HNSC	IRAK1 →	+0.923	+0.317	<.001	<.001	3	5
LSCC	BRCC3 →	+0.613	+0.431	<.001	<.001	3	5
HNSC	WDHD1 →	+0.799	+0.414	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,130 associations by consensus.

HPRT1 vs GINS2 — HNSC

Explore this scatter interactively →