HPRT1

Across TCGA pan-cancer cohorts, HPRT1 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of HPRT1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where HPRT1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HPRT1 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

HNSC, BLCA, and KIRC are the cancer types where HPRT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HPRT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.544	<.001	12	view →
BLCA	Male	III,IV	+1.177	<.001	12	view →
KIRC	Female	II,III,IV	−0.778	<.001	11	view →
STAD	Female	All	+1.215	<.001	10	view →
LUAD	Male	II,III,IV	+1.093	<.001	9	view →
COAD	All	III,IV	+0.977	<.001	9	view →
LUSC	Female	All	+1.619	<.001	7	view →
BRCA	All	III,IV	+1.206	<.001	6	view →
UCEC	All	All	+0.679	<.001	6	view →
READ	All	All	+0.932	.001	5	view →
LIHC	All	II,III,IV	+0.500	.006	5	view →
CHOL	All	II,III,IV	+1.344	.010	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

HPRT1–HNSC

Open the HNSC breakdown →