HPRT1

Across TCGA patient cohorts, HPRT1 mutation is significantly associated with the RNA expression of many other genes, with 2,539 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HPRT1-associated genes across cancer lineages are MRPS5P4, EIF3JP1, and RNU6-406P. Each is linked with HPRT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HPRT1-to-partner and partner-to-HPRT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPS5P4 grouped by HPRT1-low versus HPRT1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HPRT1→partner) and Y-score (partner→HPRT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MRPS5P4 →	+0.139	+7.816	<.001	.008	3	2
UCEC	EIF3JP1 →	+0.181	+2.327	<.001	.001	3	2
UCEC	RNU6-406P →	+0.235	+2.446	.002	.001	3	2
UCEC	RNA5SP422 →	+0.545	+1.893	.005	.008	3	2
UCEC	POM121C →	+0.443	+2.627	.001	.005	3	1
UCEC	DCP1A →	+0.491	+2.415	.007	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,539 associations by consensus.

MRPS5P4 by HPRT1 expression — SKCM

Explore this box plot interactively →