HPCA

Across TCGA cell cohorts, HPCA mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HPCA-associated genes across cancer lineages are ADIG, RIT2, and KCNG4. Each is linked with HPCA in more than 1 cancer types. Because this analysis shows association rather than direction, both HPCA-to-partner and partner-to-HPCA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADIG grouped by HPCA-low versus HPCA-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HPCA→partner) and Y-score (partner→HPCA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ADIG →	+0.038	+4.977	<.001	.007	3	2
LARGE_INTESTINE	RIT2 →	+0.029	+5.415	<.001	.004	3	1
LARGE_INTESTINE	KCNG4 →	+0.006	+5.415	<.001	.004	3	1
LARGE_INTESTINE	SIGLECL1 →	+0.018	+4.977	<.001	.007	3	1
LARGE_INTESTINE	CCER1 →	+0.012	+4.977	<.001	.007	3	1
LARGE_INTESTINE	CD300H →	+0.045	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

ADIG by HPCA expression — LARGE_INTESTINE

Explore this box plot interactively →