HPCA

Across TCGA pan-cancer cohorts, HPCA RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of HPCA’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where HPCA RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HPCA is over-expressed in tumor, although a few such as KICH and UCEC show the opposite, repressed pattern.

KIRC, HNSC, and KICH are the cancer types where HPCA tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HPCA RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	III,IV	+1.502	<.001	12	view →
HNSC	Male	III,IV	+0.408	<.001	10	view →
KICH	Female	II,III,IV	−0.602	<.001	9	view →
LUSC	All	All	+0.730	<.001	8	view →
LUAD	All	II,III,IV	+0.516	<.001	8	view →
KIRP	All	All	+0.963	<.001	7	view →
UCEC	All	All	−0.711	<.001	6	view →
READ	All	All	−0.906	<.001	5	view →
STAD	Male	All	+0.407	.007	4	view →
BRCA	All	All	+0.194	<.001	4	view →
COAD	Male	All	−0.524	.005	3	view →
LIHC	All	All	+0.101	.006	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

HPCA–KIRC

Open the KIRC breakdown →