HOXD8

Across TCGA patient cohorts, HOXD8 protein abundance is significantly associated with the RNA expression of many other genes, with 4,209 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible HOXD8-associated genes across cancer lineages are LINC01116, HOXD3, and PRPF3. Each is linked with HOXD8 in more than 3 cancer types. Because this analysis shows association rather than direction, both HOXD8-to-partner and partner-to-HOXD8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HOXD8 versus LINC01116 in OV, with a Pearson correlation of 0.56.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXD8→partner) and Y-score (partner→HOXD8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	LINC01116 →	+2.162	+0.868	<.001	<.001	3	4
UCEC	HOXD3 →	+0.973	+0.722	<.001	<.001	3	3
OV	PRPF3 →	+0.503	+0.647	.008	<.001	3	2
OV	PM20D2 →	+0.862	+0.924	.007	.001	3	2
OV	MIGA2 →	+0.758	+0.771	<.001	.002	3	2
CCRCC	DUTP7 →	+0.403	+0.323	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,209 associations by consensus.

HOXD8 vs LINC01116 — OV

Explore this scatter interactively →