HOXD8

Across TCGA pan-cancer cohorts, HOXD8 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of HOXD8’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where HOXD8 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HOXD8 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

HNSC, KIRC, and KIRP are the cancer types where HOXD8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HOXD8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	+2.136	<.001	12	view →
KIRC	Female	IV	−2.076	<.001	12	view →
KIRP	Female	All	−3.056	<.001	11	view →
KICH	Male	All	−2.598	<.001	11	view →
COAD	All	II,III,IV	−0.587	.004	9	view →
LIHC	Male	II,III,IV	+1.109	<.001	8	view →
UCEC	All	All	−3.149	<.001	6	view →
BRCA	All	III,IV	−0.856	<.001	6	view →
LUSC	Male	All	+1.083	<.001	4	view →
CHOL	All	All	+0.772	<.001	3	view →
ESCA	All	All	+0.836	.004	2	view →
PRAD	All	All	−0.546	.003	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

HOXD8–HNSC

Open the HNSC breakdown →