HOXD11

Across TCGA patient cohorts, HOXD11 RNA expression is significantly associated with the protein abundance of many other proteins, with 8,152 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HOXD11-associated proteins across cancer lineages are SEC23B, RBM47, and SCRN2. Each is linked with HOXD11 in more than 3 cancer types. Because this analysis shows association rather than direction, both HOXD11-to-partner and partner-to-HOXD11 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HOXD11 versus SEC23B in CCRCC, with a Pearson correlation of -0.39.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXD11→partner) and Y-score (partner→HOXD11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SEC23B →	-0.287	-0.524	<.001	.001	3	4
GBM	RBM47 →	-0.438	-1.072	.001	.001	3	3
GBM	SCRN2 →	-0.331	-1.063	<.001	.003	3	3
LSCC	HOXD11_S223 →	+2.231	+1.546	<.001	<.001	3	3
UCEC	SORBS3 →	+0.420	+0.947	<.001	<.001	3	3
COAD	SORBS3_S395 →	+0.614	+1.554	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,152 associations by consensus.

HOXD11 vs SEC23B — CCRCC

Explore this scatter interactively →