HOXD11

Across TCGA patient cohorts, HOXD11 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HOXD11-associated genes across cancer lineages are PCNA, ATM, and Notch1. Each is linked with HOXD11 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOXD11-to-partner and partner-to-HOXD11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by HOXD11-low versus HOXD11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXD11→partner) and Y-score (partner→HOXD11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.254	+3.000	.042	.037	3	1
UCEC	ATM →	-0.636	-3.000	.015	.037	3	1
UCEC	Notch1 →	+0.174	+3.000	.032	.037	1	2
UCEC	14-3-3_beta →	-0.132	-2.986	.023	.037	1	1
UCEC	HSP70 →	-0.483	-3.000	.037	.037	1	1
UCEC	p27_pT198 →	+0.162	+3.000	.008	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

PCNA by HOXD11 expression — UCEC

Explore this box plot interactively →