HOXD11

Across TCGA cell cohorts, HOXD11 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,676 significant associations in total. BONE shows the largest number of these associations.

The most reproducible HOXD11-associated GO terms across cancer lineages are Embryonic skeletal joint morphogenesis, Regulation of anaphase-promoting complex-dependent catabolic process, and Positive regulation of gene expression, epigenetic. Each is linked with HOXD11 in more than 8 cancer types. Because this analysis shows association rather than direction, both HOXD11-to-partner and partner-to-HOXD11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Embryonic skeletal joint morphogenesis grouped by HOXD11-low versus HOXD11-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXD11→partner) and Y-score (partner→HOXD11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Embryonic skeletal joint morphogenesis →	-0.333	-2.445	<.001	<.001	3	9
STOMACH	Regulation of anaphase-promoting complex-dependent catabolic process →	+0.109	+1.842	.008	.005	3	9
OESOPHAGUS	Positive regulation of gene expression, epigenetic →	+0.080	+2.391	<.001	.001	3	8
BONE	Chromosomal 5-methylcytosine DNA demethylation pathway →	+0.180	+3.286	<.001	<.001	3	8
OESOPHAGUS	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile →	+0.074	+2.399	.001	<.001	3	8
LUNG_NSCLC_LUSC	Alternative mRNA splicing, via spliceosome →	+0.115	+1.687	<.001	.002	2	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,676 associations by consensus.

Embryonic skeletal joint morphogenesis by HOXD11 expression — LIVER

Explore this box plot interactively →