HOXD11

Across TCGA cell cohorts, HOXD11 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HOXD11-associated genes across cancer lineages are MYF6, MYF5, and NLRP8. Each is linked with HOXD11 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOXD11-to-partner and partner-to-HOXD11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYF6 grouped by HOXD11-low versus HOXD11-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXD11→partner) and Y-score (partner→HOXD11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	MYF6 →	+1.052	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	MYF5 →	+1.326	+6.266	<.001	<.001	3	1
LUNG_NSCLC_LUAD	NLRP8 →	+0.054	+4.887	<.001	.009	3	1
BLOOD_Leukemia	H2AP →	+0.142	+4.922	<.001	.009	3	1
BLOOD_Leukemia	OR8B8 →	+0.021	+5.201	.001	.006	3	1
BLOOD_Leukemia	OR8G1 →	+0.160	+4.922	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

MYF6 by HOXD11 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →