HOXD1

Across TCGA cell cohorts, HOXD1 mutation is significantly associated with the mutation status of many other genes, with 684 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HOXD1-associated genes across cancer lineages are TEX2, OLFM1, and RNF113B. Each is linked with HOXD1 in more than 2 cancer types. Because this analysis shows association rather than direction, both HOXD1-to-partner and partner-to-HOXD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TEX2 grouped by HOXD1-low versus HOXD1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXD1→partner) and Y-score (partner→HOXD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TEX2 →	+4.239	+5.053	.007	.007	1	3
BLOOD_Leukemia	OLFM1 →	+4.321	+5.285	.005	.005	1	2
BLOOD_Leukemia	RNF113B →	+6.321	+6.321	.001	.001	1	2
BLOOD_Leukemia	SURF6 →	+4.736	+5.560	.003	.003	1	2
BLOOD_Leukemia	ADGRF1 →	+4.321	+5.285	.005	.005	1	2
BLOOD_Leukemia	EMSY →	+4.321	+5.285	.005	.005	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 684 associations by consensus.

TEX2 by HOXD1 expression — SKIN

Explore this box plot interactively →