HOXD1

Across TCGA pan-cancer cohorts, HOXD1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of HOXD1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where HOXD1 RNA is repressed in tumor relative to normal tissue. In most cancer types HOXD1 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, HNSC, and KICH are the cancer types where HOXD1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HOXD1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	III,IV	−0.960	<.001	12	view →
HNSC	Male	II,III,IV	+0.591	<.001	12	view →
KICH	Male	All	−1.809	<.001	11	view →
COAD	Female	III,IV	−1.593	<.001	11	view →
THCA	All	III,IV	+0.810	<.001	11	view →
LUSC	Female	II,III,IV	−1.201	<.001	7	view →
READ	All	All	−1.407	<.001	5	view →
LIHC	All	All	+0.183	<.001	5	view →
KIRP	All	All	−0.960	<.001	3	view →
ESCA	All	II,III,IV	+1.215	.042	2	view →
UCEC	All	All	−0.879	.012	2	view →
LUAD	Male	II,III,IV	−0.684	.008	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

HOXD1–KIRC

Open the KIRC breakdown →