HOXC8

Across TCGA patient cohorts, HOXC8 mutation is significantly associated with the RNA expression of many other genes, with 553 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HOXC8-associated genes across cancer lineages are DEFB104B, CRYAA, and ACTRT2. Each is linked with HOXC8 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOXC8-to-partner and partner-to-HOXC8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFB104B grouped by HOXC8-low versus HOXC8-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXC8→partner) and Y-score (partner→HOXC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	DEFB104B →	+0.441	+5.273	<.001	.006	3	2
READ	CRYAA →	+0.031	+5.219	<.001	.006	3	1
READ	ACTRT2 →	+0.078	+6.257	<.001	.001	3	1
READ	HELT →	+0.081	+5.421	<.001	.005	3	1
READ	RNU6-23P →	+0.444	+5.219	<.001	.006	3	1
READ	FAM99B →	+0.053	+5.039	.003	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 553 associations by consensus.

DEFB104B by HOXC8 expression — LUSC

Explore this box plot interactively →