HOXC10

Across TCGA patient cohorts, HOXC10 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HOXC10-associated genes across cancer lineages are eEF2, EGFR_pY1068, and ERK2. Each is linked with HOXC10 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOXC10-to-partner and partner-to-HOXC10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by HOXC10-low versus HOXC10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXC10→partner) and Y-score (partner→HOXC10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.275	+3.169	.044	.018	3	2
UCEC	EGFR_pY1068 →	-0.294	-2.087	.002	.005	3	2
UCEC	ERK2 →	+0.205	+2.087	.005	.005	3	2
UCEC	FoxM1 →	+0.252	+2.087	.011	.005	3	2
UCEC	ATM →	-0.525	-2.087	.002	.005	3	2
UCEC	Caspase-7-cleavedD198 →	+0.813	+2.135	<.001	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

eEF2 by HOXC10 expression — UCEC

Explore this box plot interactively →