HOXC10

Across TCGA pan-cancer cohorts, HOXC10 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated HOXC10 data layer compared with 3 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher HOXC10 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated HOXC10 expression acts as an unfavorable survival marker, although some lineages such as KIRC and KIRP show a favorable association.

ACC, KIRC, and COAD are the cancer types where HOXC10 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.200	0.713	<.001	122	view →
KIRC	OS	Median	All	0.745	0.515	<.001	65	view →
COAD	OS	Median	IV	0.306	0.816	<.001	64	view →
LGG	DFS	Median	All	0.596	0.849	<.001	54	view →
KIRP	DFS	Median	III,IV	1.000	0.207	.001	39	view →
MESO	DFS	Median	II,III,IV	0.292	0.450	.004	35	view →
UCS	DFS	Tertile	IV	0.237	0.835	.024	30	view →
LUSC	OS	Median	II,III,IV	0.533	0.693	.010	27	view →
BRCA	OS	Quartile	III,IV	0.331	0.720	.002	27	view →
READ	OS	Tertile	III,IV	0.813	0.266	.006	23	view →
THCA	OS	Tertile	All	0.881	0.982	.002	16	view →
OV	DFS	Median	II,III,IV	0.502	0.578	.032	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

HOXC10–ACC (DFS)

Open the ACC breakdown →