HOXC10

Across TCGA pan-cancer cohorts, HOXC10 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of HOXC10’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where HOXC10 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HOXC10 is over-expressed in tumor, although a few such as KICH and PRAD show the opposite, repressed pattern.

HNSC, KICH, and STAD are the cancer types where HOXC10 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HOXC10 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+3.032	<.001	12	view →
KICH	Male	II,III,IV	−3.980	<.001	10	view →
STAD	Male	III,IV	+4.015	<.001	9	view →
BRCA	All	III,IV	+2.137	<.001	8	view →
LUSC	Female	All	+2.782	<.001	7	view →
LUAD	All	All	+1.223	<.001	7	view →
ESCA	All	All	+3.285	<.001	5	view →
UCEC	All	IV	+4.450	.013	2	view →
PRAD	All	All	−0.313	.002	2	view →
COAD	Female	IV	−0.135	.006	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

HOXC10–HNSC

Open the HNSC breakdown →