HOXC-AS2

Across TCGA pan-cancer cohorts, HOXC-AS2 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated HOXC-AS2 data layer.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher HOXC-AS2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated HOXC-AS2 expression acts as an unfavorable survival marker, although some lineages such as KIRP and SKCM show a favorable association.

ACC, KIRP, and LGG are the cancer types where HOXC-AS2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	All	0.349	0.796	<.001	137	view →
KIRP	OS	Tertile	II,III,IV	0.848	0.516	.002	84	view →
LGG	DFS	Median	All	0.596	0.837	<.001	54	view →
GBM	OS	Median	All	0.318	0.502	.001	22	view →
SKCM	OS	Median	IV	0.836	0.253	<.001	21	view →
STAD	DFS	Quartile	All	0.741	0.597	.020	18	view →
ESCA	DFS	Median	II,III,IV	1.000	0.303	.004	18	view →
COAD	OS	Tertile	IV	0.336	0.626	.027	18	view →
BRCA	DFS	Quartile	IV	0.931	0.270	.010	15	view →
READ	DFS	Quartile	III,IV	0.447	0.818	.010	15	view →
LIHC	OS	Quartile	All	0.470	0.681	.013	14	view →
HNSC	OS	Tertile	All	0.655	0.816	.007	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

HOXC-AS2–ACC (OS)

Open the ACC breakdown →