HOXC-AS2

Across TCGA pan-cancer cohorts, HOXC-AS2 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of HOXC-AS2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where HOXC-AS2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HOXC-AS2 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

HNSC, KICH, and LUAD are the cancer types where HOXC-AS2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HOXC-AS2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+0.920	<.001	12	view →
KICH	Male	II,III,IV	−2.051	<.001	11	view →
LUAD	Female	All	+0.564	<.001	10	view →
STAD	Male	II,III,IV	+1.176	<.001	8	view →
BLCA	All	All	+0.643	<.001	8	view →
LUSC	Female	All	+1.480	<.001	7	view →
BRCA	All	All	+0.235	.008	6	view →
KIRC	All	II,III,IV	−0.361	.003	5	view →
COAD	All	All	+0.240	.002	5	view →
LIHC	All	All	+0.083	.001	5	view →
ESCA	All	All	+0.978	.001	2	view →
CHOL	All	All	+0.557	.020	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

HOXC-AS2–HNSC

Open the HNSC breakdown →