HOXC-AS1

Across TCGA pan-cancer cohorts, HOXC-AS1 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated HOXC-AS1 data layer.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher HOXC-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated HOXC-AS1 expression acts as an unfavorable survival marker, although some lineages such as KIRP and PCPG show a favorable association.

ACC, LGG, and KIRP are the cancer types where HOXC-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	All	0.289	0.811	<.001	139	view →
LGG	DFS	Tertile	All	0.530	0.817	<.001	54	view →
KIRP	OS	Tertile	All	0.973	0.873	.002	44	view →
COAD	DFS	Median	IV	0.335	0.645	.006	39	view →
MESO	DFS	Tertile	II,III,IV	0.298	0.497	.025	29	view →
LIHC	OS	Quartile	All	0.370	0.616	.017	22	view →
UCS	OS	Tertile	IV	0.306	0.761	.024	18	view →
PCPG	DFS	Median	All	0.946	0.641	.005	13	view →
READ	OS	Quartile	IV	0.385	0.739	.046	12	view →
PRAD	DFS	Median	All	0.711	0.868	.011	12	view →
LUAD	OS	Median	All	0.634	0.724	.010	9	view →
LUSC	DFS	Quartile	III,IV	0.475	0.712	.046	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

HOXC-AS1–ACC (OS)

Open the ACC breakdown →