HOXC-AS1

Across TCGA pan-cancer cohorts, HOXC-AS1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of HOXC-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where HOXC-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HOXC-AS1 is over-expressed in tumor, although a few such as BRCA and KICH show the opposite, repressed pattern.

HNSC, LUAD, and BRCA are the cancer types where HOXC-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HOXC-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+1.063	<.001	11	view →
LUAD	Female	All	+0.681	<.001	9	view →
BRCA	Female	All	−1.293	<.001	8	view →
KICH	Male	All	−2.460	<.001	7	view →
LUSC	Female	All	+1.620	<.001	7	view →
STAD	Male	All	+1.297	<.001	7	view →
UCEC	All	All	−1.344	.003	4	view →
BLCA	All	All	+0.745	.008	4	view →
KIRC	All	All	−0.421	.001	4	view →
ESCA	All	All	+1.416	<.001	3	view →
KIRP	All	All	−0.519	.014	3	view →
LIHC	All	All	+0.179	.010	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

HOXC-AS1–HNSC

Open the HNSC breakdown →