HOXB7

Across TCGA patient cohorts, HOXB7 mutation is significantly associated with the RNA expression of many other genes, with 827 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HOXB7-associated genes across cancer lineages are RPL31P54, IPPKP1, and RNU6-23P. Each is linked with HOXB7 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOXB7-to-partner and partner-to-HOXB7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL31P54 grouped by HOXB7-low versus HOXB7-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXB7→partner) and Y-score (partner→HOXB7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RPL31P54 →	+0.130	+5.303	.003	.006	3	2
LIHC	IPPKP1 →	+0.037	+4.720	<.001	.005	3	2
LUAD	RNU6-23P →	+0.384	+6.197	<.001	.001	3	2
SKCM	RN7SL617P →	+0.159	+5.097	<.001	.008	3	2
SKCM	MIR5688 →	+0.557	+5.436	<.001	.005	3	2
SKCM	AMMECR1LP1 →	+0.161	+5.436	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 827 associations by consensus.

RPL31P54 by HOXB7 expression — HNSC

Explore this box plot interactively →