HOXB7

Across TCGA pan-cancer cohorts, HOXB7 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of HOXB7’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where HOXB7 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HOXB7 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

HNSC, KIRC, and LUSC are the cancer types where HOXB7 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HOXB7 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+3.502	<.001	12	view →
KIRC	Female	II,III,IV	−1.180	<.001	12	view →
LUSC	Female	All	+2.312	<.001	8	view →
LUAD	Male	II,III,IV	+1.684	<.001	8	view →
KICH	Female	All	−1.642	<.001	8	view →
BLCA	All	All	+1.521	<.001	8	view →
STAD	Male	All	+1.877	<.001	7	view →
ESCA	All	All	+2.645	.009	4	view →
LIHC	Female	All	+1.099	<.001	4	view →
CHOL	All	All	+2.558	.004	3	view →
PAAD	Female	All	+2.744	.048	2	view →
UCEC	All	IV	+2.245	.015	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

HOXB7–HNSC

Open the HNSC breakdown →