HOXB-AS4

Across TCGA pan-cancer cohorts, HOXB-AS4 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated HOXB-AS4 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher HOXB-AS4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated HOXB-AS4 expression acts as an unfavorable survival marker, although some lineages such as COAD and CHOL show a favorable association.

KIRC, THYM, and UCEC are the cancer types where HOXB-AS4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.561	0.696	<.001	159	view →
THYM	DFS	Tertile	All	0.425	0.888	<.001	63	view →
UCEC	OS	Quartile	III,IV	0.304	0.780	.006	58	view →
LGG	DFS	Tertile	All	0.465	0.760	<.001	54	view →
PAAD	OS	Median	All	0.227	0.485	<.001	41	view →
COAD	OS	Tertile	All	0.856	0.562	<.001	34	view →
ACC	DFS	Quartile	All	0.440	0.866	.001	29	view →
BLCA	DFS	Median	All	0.173	0.498	<.001	24	view →
LIHC	OS	Tertile	All	0.363	0.596	.003	21	view →
CHOL	DFS	Median	III,IV	0.647	0.127	.006	20	view →
LUAD	OS	Tertile	All	0.595	0.744	.008	20	view →
DLBC	DFS	Median	III,IV	1.000	0.146	.017	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

HOXB-AS4–KIRC (OS)

Open the KIRC breakdown →